Rolas
Lab
Research
As we often say, our "arterial age" reflects our biological age. Thus, it is essential to understand how ageing of the cardiovascular system impacts vital biological systems, particularly the immune system, which is an essential function that declines with age. In line with this, we aim to advance our knowledge of how vascular ageing influences critical immune functions. This enhanced understanding will deepen our insight into how vascular ageing and immune dysregulations may contribute to cardiovascular diseases, such as stroke and myocardial infarction, which are particularly prevalent in older populations.
Specifically, our objectives include:
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Investigating the role of vascular senescence within the broader landscape of vascular ageing
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Examining the interactions between senescent vascular cells and immune cells
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Assessing the impact of vascular senescence on cardiovascular diseases
To accomplish these ambitious goals, we employ state-of-the-art molecular and cellular techniques, such as high-resolution confocal microscopy and flow cytometry. However, we are also unafraid to explore bold, innovative approaches to further our research.
Projects
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Publications
Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues
EMBO reports
Loïc Rolas, Monja Stein, Anna Barkaway, Natalia Reglero-Real, Elisabetta Sciacca, Mohammed Yaseen, Haitao Wang, Laura Vazquez-Martinez, Matthew Golding, Isobel A Blacksell, Meredith J Giblin, Edyta Jaworska, Cleo L Bishop, Mathieu-Benoit Voisin, Carles Gaston-Massuet, Liliane Fossati-Jimack, Costantino Pitzalis, Dianne Cooper, Thomas D Nightingale, Carlos Lopez-Otin, Myles J Lewis, Sussan Nourshargh
Exacerbated atherosclerosis in progeria is prevented by progerin elimination in vascular smooth muscle cells but not endothelial cells
Proceedings of the National Academy of Sciences
Ignacio Benedicto, Rosa M Carmona, Ana Barettino, Carla Espinós-Estévez, Pilar Gonzalo, Rosa M Nevado, Miguel de la Fuente-Pérez, María J Andrés-Manzano, Cristina González-Gómez, Loïc Rolas, Beatriz Dorado, Sussan Nourshargh, Magda R Hamczyk, Vicente Andrés
Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation
Immunity
Natalia Reglero-Real, Lorena Pérez-Gutiérrez, Azumi Yoshimura, Loïc Rolas, José Garrido-Mesa, Anna Barkaway, Catherine Pickworth, Rebeca S Saleeb, Maria Gonzalez-Nuñez, Shani N Austin-Williams, Dianne Cooper, Laura Vázquez-Martínez, Tao Fu, Giulia De Rossi, Matthew Golding, Mathieu-Benoit Voisin, Chantal M Boulanger, Yoshiaki Kubota, William A Muller, Sharon A Tooze, Thomas D Nightingale, Lucy Collinson, Mauro Perretti, Ezra Aksoy, Sussan Nourshargh
Cardiovascular progerin suppression and lamin A restoration rescue Hutchinson-Gilford progeria syndrome
Circulation
Amanda Sánchez-López, Carla Espinós-Estévez, Cristina González-Gómez, Pilar Gonzalo, María J Andrés-Manzano, Víctor Fanjul, Raquel Riquelme-Borja, Magda R Hamczyk, Álvaro Macías, Lara Del Campo, Emilio Camafeita, Jesús Vázquez, Anna Barkaway, Loïc Rolas, Sussan Nourshargh, Beatriz Dorado, Ignacio Benedicto, Vicente Andrés
Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage
Immunity
Anna Barkaway, Loïc Rolas, Régis Joulia, Jennifer Bodkin, Tchern Lenn, Charlotte Owen-Woods, Natalia Reglero-Real, Monja Stein, Laura Vázquez-Martínez, Tamara Girbl, Robin N Poston, Matthew Golding, Rebecca S Saleeb, Aude Thiriot, Ulrich H von Andrian, Johan Duchene, Mathieu-Benoit Voisin, Cleo L Bishop, David Voehringer, Axel Roers, Antal Rot, Tim Lämmermann, Sussan Nourshargh
Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome
Nat Med
NADPH oxidase activation in neutrophils: Role of the phosphorylation of its subunits.
European Journal of Clinical Investigation - Wiley Online Library